Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection After Alemtuzumab Treatment

@article{Kwun2012PatternsOD,
  title={Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection After Alemtuzumab Treatment},
  author={J. Kwun and B. C. Oh and A. Gibby and R. Ruhil and V. Lu and D. Kim and E. Page and O. Bulut and M. Song and A. Farris and A. Kirk and S. Knechtle and N. Iwakoshi},
  journal={American Journal of Transplantation},
  year={2012},
  volume={12}
}
  • J. Kwun, B. C. Oh, +10 authors N. Iwakoshi
  • Published 2012
  • Medicine
  • American Journal of Transplantation
  • Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development. Currently the antibody‐mediated mechanisms during CR are poorly understood due to lack of proper animal models and tools. In a clinical setting, we previously demonstrated that induction therapy by lymphocyte depletion, using alemtuzumab (anti‐human CD52), is associated with an increased incidence of serum alloantibody, C4d deposition and… CONTINUE READING
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