Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.

@article{Loffredo2008PatternsOC,
  title={Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.},
  author={John T. Loffredo and Alex Bean and Dominic R. Beal and Enrique J. L{\'e}on and Gemma E. May and Shari M. Piaskowski and Jessica R. Furlott and Jason Reed and Solomon K. Musani and Eva G Rakasz and Thomas C Friedrich and Nancy A. Wilson and David B. Allison and David I. Watkins},
  journal={Journal of virology},
  year={2008},
  volume={82 4},
  pages={1723-38}
}
Certain major histocompatibility complex (MHC) class I alleles are strongly associated with control of human immunodeficiency virus and simian immunodeficiency virus (SIV). CD8(+) T cells specific for epitopes restricted by these molecules may be particularly effective. Understanding how CD8(+) T cells contribute to control of viral replication should yield important insights for vaccine design. We have recently identified an Indian rhesus macaque MHC class I allele, Mamu-B*08, associated with… CONTINUE READING