Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi.

@article{Black2001PatternsAI,
  title={Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi.},
  author={Gillian F. Black and Hazel M. Dockrell and Amelia Catharine Crampin and Sian Floyd and Rosemary E. Weir and Lyn Bliss and Lifted Sichali and Lorren Mwaungulu and Huxley Kanyongoloka and Bagrey M.M. Ngwira and David K. Warndorff and Paul E. M. Fine},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={184 3},
  pages={322-9}
}
Interferon (IFN)-gamma responsiveness to 12 purified protein derivative (PPD) and new tuberculin antigens from 9 species of mycobacteria was assessed, using a whole blood assay, in 616 young adults living in northern Malawi, where Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccination provides no protection against pulmonary tuberculosis. The prevalence of IFN-gamma responsiveness was highest for PPDs of M. avium, M. intracellulare, and M. scrofulaceum (the MAIS complex). Correlations… CONTINUE READING
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