Patterns and Processes of Mycobacterium bovis Evolution Revealed by Phylogenomic Analyses

  title={Patterns and Processes of Mycobacterium bovis Evolution Revealed by Phylogenomic Analyses},
  author={Jos{\'e} S. L. Patan{\'e} and Joaquim P Martins and Ana Beatriz Canevari Castel{\~a}o and Christiane Nishibe and Luciana Montera and Fabiana Bigi and Mart{\'i}n Jos{\'e} Zum{\'a}rraga and Angel Cataldi and Ant{\^o}nio Augusto Fonseca J{\'u}nior and Eliana Roxo and Ana Luiza A. R. Os{\'o}rio and Klaudia SG Jorge and Tyler C Thacker and Nalvo F Almeida and Fl{\'a}bio Ribeiro de Ara{\'u}jo and Jo{\~a}o Carlos Setubal},
  booktitle={Genome biology and evolution},
Mycobacterium bovis is an important animal pathogen worldwide that parasitizes wild and domesticated vertebrate livestock as well as humans. A comparison of the five M. bovis complete genomes from the United Kingdom, South Korea, Brazil, and the United States revealed four novel large-scale structural variations of at least 2,000 bp. A comparative phylogenomic study including 2,483 core genes of 38 taxa from eight countries showed conflicting phylogenetic signal among sites. By minimizing this… CONTINUE READING
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