Patterns Prediction of Chemotherapy Sensitivity in Cancer Cell lines Using FTIR Spectrum, Neural Network and Principal Components Analysis

@inproceedings{Zendehdel2012PatternsPO,
  title={Patterns Prediction of Chemotherapy Sensitivity in Cancer Cell lines Using FTIR Spectrum, Neural Network and Principal Components Analysis},
  author={Rezvan Zendehdel and Ali Masoudi-Nejad and Farshad H. Shirazi},
  booktitle={Iranian journal of pharmaceutical research : IJPR},
  year={2012}
}
Drug resistance enables cancer cells to break away from cytotoxic effect of anticancer drugs. Identification of resistant phenotype is very important because it can lead to effective treatment plan. There is an interest in developing classifying models of resistance phenotype based on the multivariate data. We have investigated a vibrational spectroscopic approach in order to characterize a sensitive human ovarian cell line, A2780, and its cisplatin-resistant derivative, A2780-cp. In this study… CONTINUE READING
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