Patterns, puzzles and paradigms: the riddle of the homeobox

@article{Schofield1987PatternsPA,
  title={Patterns, puzzles and paradigms: the riddle of the homeobox},
  author={Paul N. Schofield},
  journal={Trends in Neurosciences},
  year={1987},
  volume={10},
  pages={3-6}
}
  • P. Schofield
  • Published 31 January 1987
  • Biology
  • Trends in Neurosciences

Figures from this paper

START domain mediates Arabidopsis GLABRA2 transcription factor dimerization and turnover independently of homeodomain DNA binding
TLDR
In vivo cycloheximide chase experiments are provided for the role of START, but not HD, in maintaining protein stability, which advances the fundamental understanding of HD-Zip TFs as multidomain regulators of epidermal development in plants. Expand
Evolutionary Potential of Cis-Regulatory Mutations to Cause Rapid Changes in Transcription Factor Binding
TLDR
The results indicate that, especially for some TF–TFBS associations, low binding specificity confers high degrees of evolvability, that is that few mutations facilitate rapid changes in transcriptional regulation, in particular for large and old TF families. Expand
Molecular characterization of HOXC8 gene and methylation status analysis of its exon 1 associated with the length of cashmere fiber in Liaoning cashmere goat
TLDR
The methylation analysis suggested that the methylation degree of HOXC8 exon 1 in anagen secondary hair follicle might be involved in regulating the growth of cashmere fiber in Liaoning cashmere goat. Expand
Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell Hyperproliferation
TLDR
It is demonstrated that oocyte-specific homeobox 1 (Obox1) can markedly enhance the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts in a proliferation-independent manner and can replace Sox2 to achieve pluripotency. Expand
Phenotype Characterization of Mice with Targeted Deletions of Dlx Enhancers
........................................................................................................................IIExpand
In-silico comparison of distal-less protein variation in insects
Distal-less (Dll) protein is the first genetic signal for limb formation to occur in the developing zygote in insects. The function seems to be different across various organisms, like the Dll inExpand
The cytoskeletal mechanics of brain morphogenesis
TLDR
This model of differentiation suggests that the genome responds to, rather than directly causes, differentiation, and follows by the synthesis of specific proteins. Expand
Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene
TLDR
This project was initiated by the isolation of the putative promoter region of the mouse myelin basic protein (MBP) gene and the presence of protein factors specifically binding to the region -609 to -577 was demonstrated by electrophoretic mobility shift assay (EMSA). Expand
Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene.
TLDR
Although the human LHX3 gene structure would provide a ground for clarification of the molecular basis of complete anterior pituitary deficiency, it was unable to identify any mutation in the LHX2 gene of 46 patients. Expand
Analysis and functional characteristics of dihydropyridine-sensitive and -insensitive calcium channel proteins.
  • N. Dascal
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1990
TLDR
This review will try to summarize briefly the current advances in the field of calcium channel proteins and outline the problems facing researchers at present on uertebrate voltage-dependent Ca*+ channels. Expand
...
1
2
...

References

SHOWING 1-10 OF 21 REFERENCES
A human homoeo box gene specifically expressed in spinal cord during embryonic development
TLDR
The nucleotide sequence of one of human complementary DNA clones containing homoeo box sequences is reported and it is shown that the corresponding gene is transcribed in human embryos and fetuses at 5–10 weeks post-conception. Expand
Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products.
TLDR
The DNA sequence of a Xhox‐1 cDNA is determined and this allows us to predict the complete sequences of a vertebrate homeobox protein. Expand
Isolation of a mouse cDNA coding for a developmentally regulated, testis‐specific transcript containing homeo box homology.
TLDR
A clone, pHBT‐1, containing sequences homologous to Drosophila homeo boxes has been isolated from a mouse testis cDNA library, and a role for the expression of the HBT‐ 1 gene in the meiotic stages of male germ cell differentiation is postulated. Expand
Phylogenetic distribution of Antennapedia-like homoeo boxes
TLDR
The phylogenetic distribution of Antp-like homoeo boxes is investigated to explore the possibility of a link between their presence and developmental strategy and give important insight into the origin of homoea boxes and the phytogeny of the animal kingdom. Expand
Spatial restriction in expression of a mouse homoeo box locus within the central nervous system
TLDR
Using Northern blot analysis and in situ hybridization to mouse tissue sections, the spatially restricted expression of a newly identified mouse homoeo box locus, Hox-3, within the central nervous system of newborn and adult mice has been demonstrated. Expand
A mouse homoeo box gene is expressed during embryogenesis and in adult kidney
TLDR
A sensitive RNase protection assay is used to examine transcription of the H24.1 gene during mouse development, and in adult tissues, to report that the gene is transcribed from as early as 7.5 days post coitum (p.c.), with maximum expression at days 11.5 and 12.5 p.c. Expand
Clustered homeo boxes are differentially expressed during murine development
TLDR
A murine homeo box known to be expressed during differentiation of embryonal carcinoma cells lies within a cluster of homeo boxes located in 30 kilobase pairs of genomic DNA, and the differential expression of these homeo-box-containing regions in various adult tissues is described. Expand
How is the mouse segmented
Abstract During mouse embryogenesis the vertebrae, ribs, muscles and dermis are all derived from about 65 paired blocks of mesodermal cells - the somites - which are laid down sequentially along theExpand
Localization of the fushi tarazu protein during Drosophila embryogenesis
TLDR
The fushi tarazu (ftz) gene of Drosophila acts early in embryogenesis to regulate body segmentation and at the later stage, ftz is expressed in each of fifteen metameric subunits of the embryo. Expand
Segmentation and neural development in vertebrates
TLDR
A prominent feature of the development of most higher organisms is the subdivision of the embryo into a series of repeating elements, or segments, and the degree to which the nervous system is involved in this process is uncertain. Expand
...
1
2
3
...