Patterning the mammalian cerebral cortex.

  title={Patterning the mammalian cerebral cortex.},
  author={Clifton W Ragsdale and Elizabeth Ann Grove},
  journal={Current opinion in neurobiology},
  volume={11 1},
When and how is the area map of the cerebral cortex set up during development? Recent studies indicate that regional pattern emerges early in cortical neurogenesis, and that this pattern does not require cues from extrinsic innervation. Studies of mutant mice indicate a role for embryonic signaling centers and for specific transcription factors in regionalizing the cortex. Thus, it is increasingly probable that the cortex is partitioned using the same types of mechanisms--and in some cases, the… CONTINUE READING

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