Patterning of the zebrafish retina by a wave of sonic hedgehog activity.

@article{Neumann2000PatterningOT,
  title={Patterning of the zebrafish retina by a wave of sonic hedgehog activity.},
  author={Carl J Neumann and C N{\"u}sslein-volhard},
  journal={Science},
  year={2000},
  volume={289 5487},
  pages={2137-9}
}
The Drosophila retina is patterned by a morphogenetic wave driven by the Hedgehog signaling protein. Hedgehog, secreted by the first neurons, induces neuronal differentiation and hedgehog expression in nearby uncommitted cells, thereby propagating the wave. Evidence is presented here that the zebrafish Hedgehog homolog, Sonic Hedgehog, is also expressed in the first retinal neurons, and that Sonic Hedgehog drives a wave of neurogenesis across the retina, strikingly similar to the wave in… CONTINUE READING
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