Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3

@article{Chisholm1995PatterningOT,
  title={Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3},
  author={Andrew D. Chisholm and H Robert Horvitz},
  journal={Nature},
  year={1995},
  volume={377},
  pages={52-55}
}
THE Pax-6 genes are important for eye development in both vertebrates and Drosophila. Mutations in the human PAX6 gene are found in patients with a variety of eye disorders, including aniridia and Peters′ anomaly1á¤-3, and mutations in the Drosophila Pax-6 homologue cause the eyeless phenotype4. In the nematode Caenorhabditis elegans vab-3 mutants display many defects in head-region development, including aberrant morphogenesis, trans-formation of hypodermal (epidermal-like) cell fates to those… CONTINUE READING

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