Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation

  title={Patterning of Muscle Acetylcholine Receptor Gene Expression in the Absence of Motor Innervation},
  author={Xia Yang and Silvia Arber and Christopher M. William and Li Li and Yasuto Tanabe and Thomas M. Jessell and Carmen Birchmeier and Steven J Burden},
The patterning of skeletal muscle is thought to depend upon signals provided by motor neurons. We show that AChR gene expression and AChR clusters are concentrated in the central region of embryonic skeletal muscle in the absence of innervation. Neurally derived Agrin is dispensable for this early phase of AChR expression, but MuSK, a receptor tyrosine kinase activated by Agrin, is required to establish this AChR prepattern. The zone of AChR expression in muscle lacking motor axons is wider… CONTINUE READING
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