Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

@article{Larson1986PatternedSA,
  title={Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation},
  author={John R. Larson and Darryl Wong and Gary Lynch},
  journal={Brain Research},
  year={1986},
  volume={368},
  pages={347-350}
}
Short, high frequency stimulation bursts (4 pulses at 100 Hz) were applied to Schaffer/commissural projections to the CA1 field of rat hippocampal slices at 0.1, 0.2, 1.0 or 2.0-s intervals to assess their efficacy in eliciting long-term potentiation (LTP). Bursts repeated at 2-s intervals induced very little LTP; shorter repetition intervals reliably elicited LTP, with the 200-ms repetition interval producing the greatest potentiation. A short-term potentiation effect, which was maximal 20 s… Expand
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