Patterned cardiovascular responses to sleep and nonrespiratory arousals in a porcine model.

@article{Launois1998PatternedCR,
  title={Patterned cardiovascular responses to sleep and nonrespiratory arousals in a porcine model.},
  author={Sandrine H Launois and Joseph H. Abraham and J. Woodrow Weiss and David A Kirby},
  journal={Journal of applied physiology},
  year={1998},
  volume={85 4},
  pages={1285-91}
}
Patients with obstructive sleep apnea experience marked cardiovascular changes with apnea termination. Based on this observation, we hypothesized that sudden sleep disruption is accompanied by a specific, patterned hemodynamic response, similar to the cardiovascular defense reaction. To test this hypothesis, we recorded mean arterial blood pressure, heart rate, iliac blood flow and vascular resistance, and renal blood flow and vascular resistance in five pigs instrumented with chronic sleep… CONTINUE READING