Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults.

@article{Yassa2011PatternSD,
  title={Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults.},
  author={Michael A. Yassa and Joyce W. Lacy and Shauna M. Stark and Marilyn S. Albert and Michela Gallagher and Craig E. L. Stark},
  journal={Hippocampus},
  year={2011},
  volume={21 9},
  pages={968-79}
}
There is widespread evidence that memory deteriorates with aging, however the exact mechanisms that underlie these changes are not well understood. Given the growing size of the aging population, there is an imperative to study age-related neurocognitive changes in order to better parse healthy from pathological aging. Using a behavioral paradigm that taxes pattern separation (the ability to differentiate novel yet similar information from previously learned information and thus avoid… CONTINUE READING
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