Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.

@article{Yi2009PatternRS,
  title={Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation.},
  author={Huanfa Yi and Xiaofei Yu and P. Gao and Yanping Wang and Sun-Hee Baek and Xing C. Chen and Hyung L. Kim and John R. Subjeck and Xiang-yang Wang},
  journal={Blood},
  year={2009},
  volume={113 23},
  pages={5819-28}
}
Class A scavenger receptor (SRA), also known as CD204, has been shown to participate in the pathogenesis of atherosclerosis and the pattern recognition of pathogen infection. However, its role in adaptive immune responses has not been well defined. In this study, we report that the lack of SRA/CD204 promotes Toll-like receptor (TLR)4 agonist-augmented tumor-protective immunity, which is associated with enhanced activation of CD8(+) effector T cell and improved inhibition of tumor growth… CONTINUE READING
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