Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes.

@article{Brown2001PatternOM,
  title={Pattern of mutation in the genome of influenza A virus on adaptation to increased virulence in the mouse lung: identification of functional themes.},
  author={Earl G. Brown and Huijun Liu and Liew Chee Kit and S. Baird and M Nesrallah},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 12},
  pages={6883-8}
}
The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of 11 mutations can convert an avirulent virus to a virulent variant that can kill at a minimal dose. Thirteen of the 14 amino acid substitutions (93%) detected among clonal isolates were likely… CONTINUE READING

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