Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice.

@article{Lee1989PatternOC,
  title={Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice.},
  author={Lela A. Lee and Kimberley K. Gaither and Silvija N. Coulter and David A. Norris and JohnB. Harley},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 5},
  pages={
          1556-62
        }
}
Subacute cutaneous lupus and neonatal lupus are closely associated with the presence of anti-Ro (SSA) autoantibodies, but there is no direct evidence establishing a role for anti-Ro (SSA) in these diseases. After parental injection into mice, IgG from sera containing anti-Ro (SSA) will bind human skin grafted onto the mice. To determine whether the antibody binding is due to anti-Ro (SSA), affinity-purified anti-Ro (SSA) and serum depleted of anti-Ro (SSA) were prepared. After injection into… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Characterization of autoantibodies associated with neonatal lupus

  • T. T. Provost, R. Watson, W. R. Gammon, M. Radowsky, J. B. Harley, M. Reichlin
  • J . Invest . Dermatol .
  • 1987

Implications of anti - Ro / Sjogren ' s syndrome A antigen autoantibody in normal sera for autoimmunity

  • J. B. Harley
  • J . Clin . Invest .
  • 1987

Neonatal lupus syndrome associated with UIRNP ( nRNP ) antibodies

  • F. Furukawa, S. Coulter, L. A. Lee, D. A. Norris
  • N . Engl . J . Med .
  • 1987

Cross - reactivity of Ro / SSA and immunoglobulin G

  • K. K. Gaither, H. Yamagata, M. J. Mamula, M. Reichlin, J. B. Harley
  • J . Exp . Med .
  • 1986

Lupus band test : clinical applications

  • R. P. Custer
  • Clinics in Dermatology
  • 1985

SSA ( Ro ) antigen expression in human fetal tissues and in neonatal and adult skin

  • S. Coulter, C. Harmon, D. A. Norris, L. A. Lee
  • J . Invest . Dermatol .
  • 1985

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