Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network.

@article{Dessaud2008PatternFI,
  title={Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network.},
  author={Eric Dessaud and Andrew P. McMahon and James Briscoe},
  journal={Development},
  year={2008},
  volume={135 15},
  pages={2489-503}
}
Neuronal subtype specification in the vertebrate neural tube is one of the best-studied examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a precise spatial order from progenitor cells according to their location along the anterior-posterior and dorsal-ventral axes. Underpinning this organization is a complex network of multiple extrinsic and intrinsic factors. This review focuses on the molecular mechanisms and general strategies at play in ventral regions of… CONTINUE READING
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