Pattern formation by dynamically interacting network motifs.

@article{Lembong2009PatternFB,
  title={Pattern formation by dynamically interacting network motifs.},
  author={Jessica Lembong and Nir Yakoby and Stanislav Y. Shvartsman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 9},
  pages={3213-8}
}
Systematic validation of pattern formation mechanisms revealed by molecular studies of development is essentially impossible without mathematical models. Models can provide a compact summary of a large number of experiments that led to mechanism formulation and guide future studies of pattern formation. Here, we realize this program by analyzing a mathematical model of epithelial patterning by the highly conserved EGFR and BMP signaling pathways in Drosophila oogenesis. The model accounts for… CONTINUE READING

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