Pattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train

  title={Pattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train},
  author={Mario Rosanova and Daniel Ulrich},
  journal={The Journal of Neuroscience},
  pages={9398 - 9405}
Spindles are non-rapid eye movement (non-REM) sleep EEG rhythms (7-14 Hz) that occur independently or in association with slow oscillations (0.6-0.8 Hz). Despite their proposed function in learning and memory, their role in synaptic plasticity is essentially unknown. We studied the ability of a neuronal firing pattern underlying spindles in vivo to induce synaptic plasticity in neocortical pyramidal cells in vitro. A spindle stimulation pattern (SSP) was extracted from a slow oscillation… 

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