Pattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train

@article{Rosanova2005PatternSpecificAL,
  title={Pattern-Specific Associative Long-Term Potentiation Induced by a Sleep Spindle-Related Spike Train},
  author={Mario Rosanova and Daniel Ulrich},
  journal={The Journal of Neuroscience},
  year={2005},
  volume={25},
  pages={9398 - 9405}
}
Spindles are non-rapid eye movement (non-REM) sleep EEG rhythms (7-14 Hz) that occur independently or in association with slow oscillations (0.6-0.8 Hz). Despite their proposed function in learning and memory, their role in synaptic plasticity is essentially unknown. We studied the ability of a neuronal firing pattern underlying spindles in vivo to induce synaptic plasticity in neocortical pyramidal cells in vitro. A spindle stimulation pattern (SSP) was extracted from a slow oscillation… 

Figures from this paper

A mechanism for learning with sleep spindles

The sequential occurrence of reactivation at the time of SWRs followed by neuronal plasticity-promoting spindles is a possible mechanism to explain NREM sleep-dependent consolidation of memories.

Differential Spike Timing and Phase Dynamics of Reticular Thalamic and Prefrontal Cortical Neuronal Populations during Sleep Spindles

It is proposed that early cortical cells serve a synchronizing role in the initiation and propagation of spindle activity, whereas the subsequent recruitment of late cells actively antagonizes the thalamic spindle generator by providing asynchronous feedback.

Cortical circuit activity underlying sleep slow oscillations and spindles

When spindles are nested in slow oscillation upstates, maximum Pyr activity appears to concur with strong perisomatic inhibition of Pyr cells via PV-Ins and low dendritic inhibition via SOM-Ins (i.e., conditions that might optimize synaptic plasticity within local cortical circuits).

Elevated Sleep Spindle Density after Learning or after Retrieval in Rats

The present study reports the first indication of learning-associated increase in spindle density in the rat, providing an animal model to study the role of brain oscillations in memory consolidation during sleep and substantially extend findings in humans.

Large Scale Cortical Functional Networks Associated with Slow-Wave and Spindle-Burst-Related Spontaneous Activity

This work highlights two specific forms of brain activity: slow-wave activity in the adult brain and spindle bursts in developing brain, which are prominent and well-studied forms of spontaneous activity that will yield valuable insights into brain function in the coming years.

Circuit plasticity during up-states in mouse barrel cortex

The results indicate that after conducting a pairing protocol experiment in up-states, it is observed LTD effects duo to a significant reduction of slope levels and weakening neural strength (EPSPs), remarkable to mention that targeting the endocannabinoid system may aid in the treatment of disorder associated with impaired extinction-like processes.

Cellular mechanisms of burst firing‐mediated long‐term depression in rat neocortical pyramidal cells

During wakefulness and sleep, neurons in the neocortex emit action potentials tonically or in rhythmic bursts, respectively. However, the role of synchronized discharge patterns is largely unknown.

rhythm-regulation and plasticity

Thalamic oscillations of low-vigilance states have a “plasticity function” that can shape on-going oscillations during inattention and non-REM sleep and may potentially reconfigure thalamic networks for faithful information processing during attentive wakefulness.

Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations

It is reported that interaction between slow cortical oscillations and synaptic plasticity during deep sleep can underlie mapping hippocampal memory traces to persistent cortical representation.
...

References

SHOWING 1-10 OF 66 REFERENCES

Intracellular analysis of relations between the slow (< 1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram

The data indicate that the thalamus is not essentially implicated in the genesis of the slow rhythm, and through the contralateral thalamocortical systems and callosal projections, also transected the corpus callosum in thalamically lesioned animals, and still recorded theslow rhythm in cortical neurons.

Firing Mode-Dependent Synaptic Plasticity in Rat Neocortical Pyramidal Neurons

It is concluded that intrinsic burst firing represents a signal for resetting excitatory synaptic weights, and was robust over a wide range of intervals between -100 and +200 msec, and depression was maximal for closely spaced presynaptic and postsynaptic events.

Spindle oscillation in cats: the role of corticothalamic feedback in a thalamically generated rhythm.

It is proposed that the waxing pattern of spindle oscillation is due to a progressive entrainment of units into the oscillation until a maximum number is reached, depending on the background activity in the network.

Cellular basis of EEG slow rhythms: a study of dynamic corticothalamic relationships

  • D. ContrerasM. Steriade
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
During low-frequency oscillatory states, characteristic of slow-wave sleep, neocortical and thalamic neurons display phase relations that are restricted to narrow time windows, and that synchronization results from a generalized inhibitory phenomenon.

A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components

A novel slow oscillation in intracellular recordings from cortical association areas 5 and 7, motor areas 4 and 6, and visual areas 17 and 18 of cats under various anesthetics is described and synchronous inhibitory periods in both neurons are demonstrated.

Spatiotemporal Analysis of Local Field Potentials and Unit Discharges in Cat Cerebral Cortex during Natural Wake and Sleep States

The results show that natural SWS in cats is characterized by slow-wave complexes, synchronized over large cortical territories, interleaved with brief periods of fast oscillations, characterized by local synchrony, and of characteristics similar to that of the sustainedfast oscillations of activated states.

Neuronal Plasticity in Thalamocortical Networks during Sleep and Waking Oscillations

Long-Lasting Novelty-Induced Neuronal Reverberation during Slow-Wave Sleep in Multiple Forebrain Areas

The results indicate that persistent experience-dependent neuronal reverberation is a general property of multiple forebrain structures, and does not consist of an exact replay of previous activity, but instead it defines a mild and consistent bias towards salient neural ensemble firing patterns.

The Sleep Slow Oscillation as a Traveling Wave

It is shown here that each cycle of the slow oscillation is a traveling wave, which provides a blueprint of cortical excitability and connectivity and may play a role in spike timing-dependent synaptic plasticity during sleep.
...