Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb

@article{Sahay2011PatternSA,
  title={Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb},
  author={Amar Sahay and Donald A Wilson and Ren{\'e} Hen},
  journal={Neuron},
  year={2011},
  volume={70},
  pages={582-588}
}
While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng… CONTINUE READING
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