Pattern Recognition Receptors and Inflammation

@article{Takeuchi2010PatternRR,
  title={Pattern Recognition Receptors and Inflammation},
  author={Osamu Takeuchi and Shizuo Akira},
  journal={Cell},
  year={2010},
  volume={140},
  pages={805-820}
}
View on Elsevier
cell.com
6,815 Citations
Highly Influential Citations
545
Background Citations
3,413
Methods Citations
56
Results Citations
14

Figures and Tables from this paper

6,815 Citations

Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.

This review discusses the recent developments in microbial recognition by Toll-like receptors (TLRs) and intracellular nucleic acid sensors and the signaling pathways initiated by them.

Toll-Like Receptors

Innate signaling in the inflammatory immune disorders.

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

The recent advances in TLR signaling cross talks and the mechanism of pathogen recognition are discussed with special emphasis on the role of TLRs in tumor immunity and TLR-targeted therapeutics.

Extracellular pattern recognition molecules in health and diseases

Accumulating evidence indicates that extracellular PRMs are important components of the humoral arm of innate immunity, able to recognize a variety of pathogenic agents and eliminate them through shared common mechanisms including complement activation, opsonization, agglutination, neutralization and regulation of inflammation.

Signaling in innate immunity and inflammation.

Although the role of inflammation is to resolve infection and injury, increasing evidence indicates that chronic inflammation is a risk factor for cancer.

Pathogen Recognition by the Innate Immune System

In this review, a comprehensively review the recent progress in the field of PAMP recognition by PRRs and the signaling pathways activated byPRRs.

Pattern-recognition Receptors in Pulp Defense

The expression of PRRs in human dental pulp cells are reviewed, namely, receptors from the Toll-like (TLR) and Nod-like NLR families, by which cells recognize bacteria, which represent, in the tooth, the first line of defense for the host.

Cellular and molecular regulation of innate inflammatory responses

Some of the recent advances in the understanding of the cellular and molecular mechanisms for the establishment and regulation of innate immunity and inflammatory responses are discussed.

Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections

The role played by intracellular pattern recognition receptors both in controlling the infection and in the host's susceptibility against the main fungi of medical relevance is highlighted.
...

References

SHOWING 1-10 OF 155 REFERENCES

Pathogen Recognition and Innate Immunity

Innate immune recognition of viral infection

Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids and induce type I interferon responses via distinct signaling pathways.

Activation of innate immune antiviral response by NOD2

The function of Nod2 as a viral PRR highlights the important function ofNod2 in host antiviral defense mechanisms.

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

It is reported that TLR2 activation by viruses led to the production of type I interferon, and it is demonstrated that this specialized response was mediated by Ly6Chi inflammatory monocytes.

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

This work shows that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers.

Signalling through C-type lectin receptors: shaping immune responses

The role of CLR signalling in regulating adaptive immunity and immunopathogenesis is described and how this knowledge can be harnessed for the development of innovative vaccination approaches is discussed.

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.

Innate immunity to virus infection

This review discusses recent advances in the understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses.

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

Cell type-specific involvement of RIG-I in antiviral response.

...