Pattern Recognition Receptors and Inflammation

@article{Takeuchi2010PatternRR,
  title={Pattern Recognition Receptors and Inflammation},
  author={Osamu Takeuchi and Shizuo Akira},
  journal={Cell},
  year={2010},
  volume={140},
  pages={805-820}
}

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References

SHOWING 1-10 OF 155 REFERENCES

Pathogen Recognition and Innate Immunity

Innate immune recognition of viral infection

Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids and induce type I interferon responses via distinct signaling pathways.

Activation of innate immune antiviral response by NOD2

The function of Nod2 as a viral PRR highlights the important function ofNod2 in host antiviral defense mechanisms.

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

This work shows that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers.

Signalling through C-type lectin receptors: shaping immune responses

The role of CLR signalling in regulating adaptive immunity and immunopathogenesis is described and how this knowledge can be harnessed for the development of innovative vaccination approaches is discussed.

TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

A profilin-like molecule from the protozoan parasite Toxoplasma gondii is identified that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88 and is the first chemically defined ligand for this TLR.

Innate immunity to virus infection

This review discusses recent advances in the understanding of the mechanisms of viral RNA recognition by these different types of receptors and its relation to acquired immune responses.

Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

Dectin-2 constitutes a major fungal PRR that can couple to the Syk–CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

Cell type-specific involvement of RIG-I in antiviral response.

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

It is shown that TRAF3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro- inflammatory cytokines, owing to defective IL-10 production.
...