Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

@inproceedings{Kosmaczewska2013PatientsWT,
  title={Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement},
  author={Agata Kosmaczewska and Jerzy Świerkot and Lidia Ciszak and Aleksandra Szteblich and Agnieszka Chrobak and Lidia Karabon and Anna Partyka and Jacek Szechiński and Piotr Wiland and Irena Frydecka},
  booktitle={Rheumatology International},
  year={2013}
}
Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this process has been recently attributed to Th1 responses. The aim of the study was to estimate the extent of Th1/Th17/Treg imbalance in peripheral blood (PB) of patients with short- and long-term RA in… CONTINUE READING
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