Patients with severe atopic dermatitis have activated circulating basophils.

  title={Patients with severe atopic dermatitis have activated circulating basophils.},
  author={John V. James and Anne Kagey-Sobotka and Hugh A Sampson},
  journal={The Journal of allergy and clinical immunology},
  volume={91 6},
BACKGROUND The purpose of this study was to define the potential role of the basophil in the pathogenesis of atopic dermatitis by comparing basophil releasibility in patients with food allergy and either mild or severe atopic dermatitis. METHODS A clinical scoring system was used to differentiate patients into either a low clinical score (LCS) group, 10 patients, or a high clinical score (HCS) group, 14 patients. Basophil histamine release was measured with a radioenzymatic assay, and… CONTINUE READING


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