Patients with refractory reflux symptoms: What do they have and how should they be managed?

@article{Kahrilas2015PatientsWR,
  title={Patients with refractory reflux symptoms: What do they have and how should they be managed?},
  author={Peter J. Kahrilas and L Keefer and John E. Pandolfino},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2015},
  volume={27 9},
  pages={1195-201}
}
With the widespread use of proton pump inhibitors (PPIs), the frontier of treating reflux disease has shifted from refractory esophagitis to PPI-refractory symptoms. However, symptoms are inherently less specific than mucosal disease and, as noted by Herregods et al. in their contribution appearing in this issue of Neurogastroenterology and Motility… CONTINUE READING