Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.

@article{Kakumanu2008PatientsWP,
  title={Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptide.},
  author={Prasanthi Kakumanu and Hajime Yamagata and Eric S. Sobel and Westley H. Reeves and Edward K. L. Chan and Minoru Satoh},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 6},
  pages={1576-81}
}
OBJECTIVE The anti-cyclic citrullinated peptide (anti-CCP) enzyme-linked immunosorbent assay (ELISA) has high sensitivity and specificity for rheumatoid arthritis (RA). However, detection of anti-CCP in patients with active pulmonary tuberculosis (TB) has recently been reported. To determine whether this activity was specific for the citrullinated residue, the specificity of anti-CCP-positive sera for CCP versus that for unmodified arginine-containing peptide (CAP) was examined in patients with… CONTINUE READING