Patients with non-relapsing ANCA-associated vasculitis have increased numbers of circulating IL-10 producing Th17 cells

Abstract

Introduction/aim IL-17 producing T-cells (Th17) were recently defined as a new, pro-inflammatory T-cell subset and are considered to have a key role in autoimmune diseases. Importantly, it was recently described that anti-inflammatory regulatory T-cells (Treg) are able to convert to pro-inflammatory Th17 cells (“Plasticity”) and vice versa. Little is known about the Th17 response or plasticity in ANCA-associated vasculitis (AAV). Therefore, we investigated Th17 responses in AAV.

DOI: 10.1186/1479-5876-8-S1-P62

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Cite this paper

@inproceedings{Wilde2010PatientsWN, title={Patients with non-relapsing ANCA-associated vasculitis have increased numbers of circulating IL-10 producing Th17 cells}, author={Benjamin G. Wilde and Mari{\"{e}lle Thewissen and Pieter van Paassen and M. A. Hilhorst and Jan G. M. C. Damoiseaux and Oliver Witzke and Jan Willem Cohen Tervaert}, booktitle={Journal of Translational Medicine}, year={2010} }