Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits.

@article{Miwa2001PatientsWC,
  title={Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits.},
  author={Jun Miwa and Hirotoshi Echizen and Kei Matsueda and Noritsugu Umeda},
  journal={Digestion},
  year={2001},
  volume={63 3},
  pages={188-94}
}
BACKGROUND Serotonin (5-HT) may play an important role in the regulation of colonic motility in humans. However, it is not known whether alterations in the colonic 5-HT system are involved in the pathophysiology of irritable bowel syndrome (IBS). METHODS Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation-predominant IBS (n = 7 and n = 8, respectively) and from subjects with normal bowel habits (n = 7) by… CONTINUE READING

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Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
DefecationIs related toDiarrhea
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
DiarrheaIs related toDefecation
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
IntestinesIs associated anatomic site ofIrritable Bowel Syndrome
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
However , it is not known whether alterations in the colonic 5-HT system are involved in the pathophysiology of irritable bowel syndrome ( IBS ) . METHODS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Although the mucosal 5-HT concentrations were elevated in patients with constipation - predominant IBS as compared with those with diarrhea - predominant IBS and the control subjects , further studies are necessary to determine whether the elevated mucosal 5-HT is a cause or a result of abnormal colonic motility .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
Patients with constipation - predominant irritable bowel syndrome ( IBS ) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea - predominant patients and subjects with normal bowel habits .
In addition , the overall mean mucosal 5-HT concentrations obtained from patients with constipation - predominant IBS were significantly ( p < 0.05 ) higher than those obtained from the control subjects and patients with diarrhea - predominant IBS .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
RectumSibling in part ofAscending colon
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Ascending colonSibling in part ofRectum
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Ascending colonAnatomic structure is physical part ofColon structure (body structure)
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
Colonic mucosal specimens ranging from the ascending colon to the rectum were obtained from patients with diarrhea- or constipation - predominant IBS ( n = 7 and n = 8 , respectively ) and from subjects with normal bowel habits ( n = 7 ) by endoscopic biopsy in order to determine whether patients with different clinical manifestations of IBS have different mucosal disposition of 5-HT .
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