Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells.

@article{Cavani1998PatientsWA,
  title={Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells.},
  author={Andrea Cavani and Donglan Mei and Emanuela Guerra and Silvia Corinti and Mauro Giani and Lia Pirrotta and Pietro Puddu and Giampiero Girolomoni},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 4},
  pages={
          621-8
        }
}
To investigate the mechanisms underlying the expression of allergic contact dermatitis, we compared the characteristics of nickel (Ni)-specific T cell responses in 10 patients with allergic contact dermatitis to Ni and in 10 healthy, nonallergic individuals. CD4+ T cells purified from peripheral blood of both allergic and nonallergic subjects proliferated similarly to NiSO4 in vitro, with the responses mostly restricted to CD4+ CD45RO+ memory T cells. In contrast, Ni-specific CD8+ T cell… CONTINUE READING
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