Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells.

@article{Baumgart2005PatientsWA,
  title={Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells.},
  author={Daniel C Baumgart and Diana Metzke and Juergen Schmitz and Alexander Scheffold and Andreas Sturm and Bertram J Wiedenmann and Axel Dignass},
  journal={Gut},
  year={2005},
  volume={54 2},
  pages={228-36}
}
BACKGROUND Breakdown of tolerance against the commensal microflora is believed to be a major factor in the pathogenesis of inflammatory bowel disease (IBD). Dendritic cells (DC) have been implicated in this process in various animal models, but data on human DC in IBD are very limited. AIM To characterise plasmacytoid DC (PDC) and myeloid DC (MDC) in patients with active versus inactive IBD and healthy controls. PATIENTS AND METHODS Peripheral blood was obtained from 106 patients (Crohn's… CONTINUE READING

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