Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal.

@article{Wergedal2003PatientsWV,
  title={Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal.},
  author={Jon E. Wergedal and Katarina Veskovic and Minea Hellan and Christine Nyght and Wendy Balemans and Cesar Libanati and F. M. H. M. Vanhoenacker and Johan Tan and David J. Baylink and Wim van Hul},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 12},
  pages={5778-83}
}
Van Buchem disease is an autosomal recessive disease characterized by overgrowth of the skeleton. In a group of Dutch patients the disease is thought to be due to a 52-kb deletion that results in decreased expression of the SOST gene. To further characterize the disease, the morphology of the metacarpals of six adult subjects and two juveniles with Van Buchem disease were measured on hand x-rays along with nine normal adults and nine adult carriers of the disease. Serum bone formation markers… CONTINUE READING

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