Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia.

  title={Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia.},
  author={John M. Olichney and Jason R. Taylor and James R Gatherwright and David P. Salmon and Amanda J. Bressler and Marta Kutas and Vicente J Iragui-Madoz},
  volume={70 19 Pt 2},
OBJECTIVE We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI). BACKGROUND Two ERP components, the P600 and N400, are sensitive to abnormal episodic/declarative memory and semantic processing. When congruous category-exemplars are repeated, smaller P600s (relative to initial presentation) are normally elicited. Repetitions of semantically incongruous words yield smaller N400 amplitude. In… CONTINUE READING


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