Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

@article{Hartmann2010PatientsWI,
  title={Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas},
  author={Christian Hartmann and Bettina Hentschel and Wolfgang Wick and David Capper and Joerg Felsberg and Miranda Simon and Manfred Westphal and Gabriele Schackert and Richard Meyermann and Torsten Pietsch and Guido Reifenberger and Michael Weller and Markus L{\"o}ffler and Andreas von Deimling},
  journal={Acta Neuropathologica},
  year={2010},
  volume={120},
  pages={707-718}
}
WHO grading of human brain tumors extends beyond a strictly histological grading system by providing a basis predictive for the clinical behavior of the respective neoplasm. For example, patients with glioblastoma WHO grade IV usually show a less favorable clinical course and receive more aggressive first-line treatment than patients with anaplastic astrocytoma WHO grade III. Here we provide evidence that the IDH1 status is more prognostic for overall survival than standard histological… CONTINUE READING