Patients with Fabry Disease after Enzyme Replacement Therapy Dose Reduction and Switch-2-Year Follow-Up.

@article{Lenders2016PatientsWF,
  title={Patients with Fabry Disease after Enzyme Replacement Therapy Dose Reduction and Switch-2-Year Follow-Up.},
  author={M. Lenders and S. Canaan-K{\"u}hl and J. Kr{\"a}mer and T. Duning and S. Reiermann and C. Sommer and J. Stypmann and D. Blaschke and N. {\"U}çeyler and H. Hense and S. Brand and C. Wanner and F. Weidemann and E. Brand},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 3},
  pages={
          952-62
        }
}
Because of the shortage of agalsidase-β supply between 2009 and 2012, patients with Fabry disease either were treated with reduced doses or were switched to agalsidase-α. In this observational study, we assessed end organ damage and clinical symptoms with special focus on renal outcome after 2 years of dose-reduction and/or switch to agalsidase-α. A total of 89 adult patients with Fabry disease who had received agalsidase-β (1.0 mg/kg body wt) for >1 year were nonrandomly assigned to continue… Expand
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