Patients with ERCC1-negative locally advanced esophageal cancers may benefit from preoperative chemoradiotherapy.

@article{Kim2008PatientsWE,
  title={Patients with ERCC1-negative locally advanced esophageal cancers may benefit from preoperative chemoradiotherapy.},
  author={Min Kyoung Kim and Kyung-Ja Cho and Gui Young Kwon and Seung Il Park and Yong Hee Kim and Jong Hoon Kim and H-y Song and Ji Hoon Shin and Hwoon Yong Jung and Gin Hyug Lee and Kee Don Choi and Sung- Bae Kim},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 13},
  pages={4225-31}
}
PURPOSE To assess the significance of excision repair cross-complementation group 1 (ERCC1) expression as a predictive marker, we analyzed the effects of preoperative chemoradiotherapy on survival relative to ERCC1 status in patients with locally advanced operable esophageal cancer. EXPERIMENTAL DESIGN Paraffin-embedded pretreatment tumor specimens, collected by endoscopic biopsy from patients treated with surgery alone or with preoperative chemoradiotherapy followed by surgery, were… CONTINUE READING

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