Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma

@article{Caruso2015PatientsTF,
  title={Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma},
  author={Donatella Caruso and Federico Abbiati and Silvia Giatti and Simone Romano and Roberto Cosimo Melcangi},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2015},
  volume={146},
  pages={74-79}
}
Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported even after discontinuation of finasteride treatment. Due to the capability of finasteride to block the metabolism of progesterone (PROG) and/or testosterone (T) we have evaluated, by liquid chromatography-tandem mass spectrometry, the levels of several neuroactive steroids in paired plasma and cerebrospinal… CONTINUE READING

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