Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.

@article{Garbern2002PatientsLT,
  title={Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation.},
  author={J. Garbern and D. Yool and G. Moore and I. B. Wilds and M. W. Faulk and M. Klugmann and Klaus-Amin Nave and E. Sistermans and M. S. van der Knaap and T. Bird and M. Shy and J. Kamholz and I. Griffiths},
  journal={Brain : a journal of neurology},
  year={2002},
  volume={125 Pt 3},
  pages={
          551-61
        }
}
Axonal degeneration contributes to clinical disability in the acquired demyelinating disease multiple sclerosis. Axonal degeneration occurs during acute attacks, associated with inflammation, and during the chronic progressive phase of the disease in which inflammation is not prominent. To explore the importance of interactions between oligodendrocytes and axons in the CNS, we analysed the brains of rodents and humans with a null mutation in the gene encoding the major CNS myelin protein… Expand
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