Patients at high risk of progression after radical prostatectomy: do they all benefit from immediate post-operative irradiation? (EORTC trial 22911).

@article{Collette2005PatientsAH,
  title={Patients at high risk of progression after radical prostatectomy: do they all benefit from immediate post-operative irradiation? (EORTC trial 22911).},
  author={Laurence Collette and Hendrik van Poppel and Michel Bolla and Paul J van Cangh and Kris Vekemans and Luigi Filippo Da Pozzo and Theo M de Reijke and Antony C Verbaeys and J P Bosset and Marianne Pi{\'e}rart},
  journal={European journal of cancer},
  year={2005},
  volume={41 17},
  pages={2662-72}
}
EORTC trial 22911 demonstrated that immediate postoperative irradiation significantly improved biochemical failure free survival (BPFS) compared to wait-and-see (W and S) until relapse in patients with pT2-3 tumours and pathological risk factors after radical prostatectomy. In this study, we have investigated the heterogeneity of the treatment benefit across defined subgroups of patients. Data from 972 patients were used. A risk model was developed in the W and S group and the Log-rank test for… CONTINUE READING