Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression

  title={Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression},
  author={Rosalind Watts and Camilla M Day and Jacob Krzanowski and David J. Nutt and Robin Lester Carhart-Harris},
  journal={Journal of Humanistic Psychology},
  pages={520 - 564}
Objective: To identify patients’ perceptions of the value of psilocybin as a treatment for depression. Method: Twenty patients enrolled in an open-label trial of psilocybin for treatment-resistant depression participated in a semistructured interview at 6-month follow-up. Thematic analysis was used to identify patients’ experiences of the treatment and how it compared with previous treatments. Results: Two main change processes were identified in relation to the treatment. The first concerned… 

Tables from this paper

Psychedelic therapy for smoking cessation: Qualitative analysis of participant accounts

The findings highlight the value of qualitative research in the psychopharmacological investigation of psychedelics and describe perceived connections between drug- and non-drug factors, and provide suggestions for future research trial design and clinical applications.

An Interpretative Phenomenological Analysis of the use of psilocybin by veterans with symptoms of trauma

Veterans are at increased risk of experiencing symptoms of trauma. Although many benefit from available treatments, some find treatment inaccessible or ineffective and explore alternative substances.

Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy for Depression

Background: Across psychotherapeutic frameworks, the strength of the therapeutic alliance has been found to correlate with treatment outcomes; however, its role has never been formally assessed in a

The Psychedelic Debriefing in Alcohol Dependence Treatment: Illustrating Key Change Phenomena through Qualitative Content Analysis of Clinical Sessions

This study is unique in analyzing actual clinical sessions, as opposed to interviews of patients conducted separately from treatment, shedding light on potential therapeutic mechanisms of change and how participants express effects of psilocybin.

The Role of Psilocybin-Assisted Psychotherapy to Support Patients With Cancer: A Critical Scoping Review of the Research

  • R. LehtoMegan MillerJ. Sender
  • Psychology, Medicine
    Journal of holistic nursing : official journal of the American Holistic Nurses' Association
  • 2021
Although psilocybin-assisted psychotherapy is in early stages of clinical testing, it shows promise for carefully screened patients with cancer who have persistent existential suffering and it will be critical for investigators to tailor this emerging intervention to select patients and for clinicians to be engaged in assessment of outcomes and efficacy.

Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation

Psychedelic therapy shows promise as a novel intervention for a wide range of mental health concerns but its therapeutic action is incompletely understood. In line with acceptance and commitment

Self-Care Practices with Psychedelics - A Qualitative Study of Users' Perspectives.

This article explores the psychedelic experience from the users' point of view and through the lens of self-care, a concept within the domain of health and well-being. In a time of renewed interest

Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

The view that the quality of the acute psychedelic experience is a key mediator of long-term changes in mental health is bolstered, as data from a clinical trial assessing psilocybin for treatment-resistant depression confirmed this.

The hidden therapist: evidence for a central role of music in psychedelic therapy

This study indicates that music plays a central therapeutic function in psychedelic therapy, with welcome and “unwelcome” influences on patients’ subjective experiences.

The Incorporation of Indigenous Tradition in Psychedelic-Assisted Psychotherapy: A Pathway to Cultural Inclusivity Within Mental Health

2 Introduction 3 Decriminalization of Psychedelics in Oakland, Denver, Santa Cruz, Oregon and Washington D.C. 6 Section 1: Epistemology of Psychedelics 9 Chapter 1. Psychedelic Use in the United



Patient Experiences of Psilocybin-Assisted Psychotherapy: An Interpretative Phenomenological Analysis

The psychological mechanisms of action involved in psilocybin-assisted psychotherapy are not yet well understood. Despite a resurgence of quantitative research regarding psilocybin, the current study

LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects

Evaluations of subjective experiences suggest facilitated access to emotions, confrontation of previously unknown anxieties, worries, resources and intense emotional peak experiences à la Maslow as major psychological working mechanisms in patients with life-threatening diseases.

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

Psilocybin was associated with enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress, sustained benefits in existential distress and quality of life, as well as improved attitudes towards death.

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

A single-group proof-of-concept study to quantify acute effects of psilocybin in alcohol-dependent participants and to provide preliminary outcome and safety data, providing a strong rationale for controlled trials with larger samples to investigate efficacy and mechanisms.

Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer.

This study established the feasibility and safety of administering moderate doses of psilocybin to patients with advanced-stage cancer and anxiety and revealed a positive trend toward improved mood and anxiety.

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety.

A Randomized Controlled Effectiveness Trial of Acceptance and Commitment Therapy and Cognitive Therapy for Anxiety and Depression

Overall, the results suggest that ACT is a viable and disseminable treatment, the effectiveness of which appears equivalent to that of CT, even as its mechanisms appear to be distinct.

Long-term follow-up of psilocybin-facilitated smoking cessation

The results suggest that in the context of a structured treatment program, psilocybin holds considerable promise in promoting long-term smoking abstinence, adding to recent and historical evidence suggesting high success rates when using classic psychedelics in the treatment of addiction.

Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness

Assessment of the effect of psilocybin on changes in the five broad domains of personality – Neuroticism, Extroversion, Openness, Agreeableness, and Conscientiousness found significant increases in Openness following a high-dose p silocybin session.