Patient-specific dosimetry in predicting renal toxicity with (90)Y-DOTATOC: relevance of kidney volume and dose rate in finding a dose-effect relationship.

@article{Barone2005PatientspecificDI,
  title={Patient-specific dosimetry in predicting renal toxicity with (90)Y-DOTATOC: relevance of kidney volume and dose rate in finding a dose-effect relationship.},
  author={Raffaella Barone and Françoise Borson-Chazot and Roelf Valkema and St{\'e}phane Walrand and Franck Chauvin and Lida N. Gogou and Larry K. Kvols and Eric Paul Krenning and François Jamar and Stanislas P. Pauwels},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2005},
  volume={46 Suppl 1},
  pages={
          99S-106S
        }
}
UNLABELLED Nephrotoxicity is the major limiting factor during therapy with the radiolabeled somatostatin analog (90)Y-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-d-Phe(1)-Tyr(3)-octreotide (DOTATOC). Pretherapeutic assessment of kidney absorbed dose could help to minimize the risk of renal toxicity. The aim of this study was to evaluate the contribution of patient-specific adjustments to the standard dosimetric models, such as the renal volume and dose rate, for… CONTINUE READING

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