Patient-specific dose finding based on bivariate outcomes and covariates.

  title={Patient-specific dose finding based on bivariate outcomes and covariates.},
  author={Peter F. Thall and Hoang Q Nguyen and Elihu Estey},
  volume={64 4},
SUMMARY A Bayesian sequential dose-finding procedure based on bivariate (efficacy, toxicity) outcomes that accounts for patient covariates and dose-covariate interactions is presented. Historical data are used to obtain an informative prior on covariate main effects, with uninformative priors assumed for all dose effect parameters. Elicited limits on the probabilities of efficacy and toxicity for each of a representative set of covariate vectors are used to construct bounding functions that… CONTINUE READING


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