Patient-specific decision-making for warfarin therapy in nonvalvular atrial fibrillation: how will screening with genetics and imaging help?

@article{Eckman2008PatientspecificDF,
  title={Patient-specific decision-making for warfarin therapy in nonvalvular atrial fibrillation: how will screening with genetics and imaging help?},
  author={Mark H. Eckman and Lawrence Ka Sing Wong and Yannie Oi Yan Soo and W. Lam and Song Ran Yang and Steven A. Greenberg and Jonathan Rosand},
  journal={Stroke},
  year={2008},
  volume={39 12},
  pages={3308-15}
}
BACKGROUND AND PURPOSE Intracerebral hemorrhage (ICH) accounts for a majority of long-term morbidity and mortality associated with bleeding while on warfarin. Both ICH and warfarin-related ICH appear to have a genetic component. Furthermore, advanced neuroimaging using MRI can now identify individuals at increased risk of ICH. We explore whether screening strategies that include genetic profiling and neuroimaging might improve the safety of chronic anticoagulation for atrial fibrillation by… CONTINUE READING