Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature.

@article{Nguyen2007PatientSC,
  title={Patient selection, cancer control, and complications after salvage local therapy for postradiation prostate-specific antigen failure: a systematic review of the literature.},
  author={Paul Linh Nguyen and Anthony V. D'Amico and Andrew K. Lee and W. Warren Suh},
  journal={Cancer},
  year={2007},
  volume={110 7},
  pages={1417-28}
}
Among men who experience prostate-specific antigen (PSA) failure after external beam radiation or brachytherapy (RT), many will harbor occult micrometastases; however, a significant minority will have a true local-only failure and, thus, potentially may benefit from a salvage local therapy. Those most likely to have a local-only failure initially have low-risk disease (PSA < 10 ng/mL, Gleason score < or =6, clinical T1c or T2a tumor status), pretreatment PSA velocity < 2.0 ng/mL per year at the… CONTINUE READING

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