Patient-derived xenografts for individualized care in advanced sarcoma

  title={Patient-derived xenografts for individualized care in advanced sarcoma},
  author={Justin Stebbing and Keren Paz and Gary K. Schwartz and Leonard H. Wexler and Robert Maki and Raphael E Pollock and Ronnie Morris and Richard Cohen and Arjun Shankar and Glen Blackman and Victoria F Harding and David R. V{\'a}squez and Jonathan Krell and Daniel Ciznadija and Amanda B. Katz and David Sidransky},
BACKGROUND Patients with advanced, metastatic sarcoma have a poor prognosis, and the overall benefit from the few standard-of-care therapeutics available is small. The rarity of this tumor, combined with the wide range of subtypes, leads to difficulties in conducting clinical trials. The authors previously reported the outcome of patients with a variety of common solid tumors who received treatment with drug regimens that were first tested in patient-derived xenografts using a proprietary… CONTINUE READING