Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors.

@article{Izumchenko2017PatientderivedXE,
  title={Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors.},
  author={Eugene A Izumchenko and Keren Paz and Daniel Ciznadija and Ido Sloma and Amanda M. Katz and D Vasquez-Dunddel and Ilan Ben-Zvi and Justin Stebbing and Warren McGuire and Warren Harris and Ryosuke Maki and Andy Gaya and Arjun Bedi and Stergios Zacharoulis and Rajani K Ravi and Leonard H. Wexler and Mohammad Obaidul Hoque and Carlos Rodriguez-Galindo and Harvey I. Pass and Nejama Peled and Angela Davies and Ronnie Morris and Maartje Hidalgo and David Sidransky},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2017},
  volume={28 10},
  pages={
          2595-2605
        }
}
Background While patient-derived xenografts (PDXs) offer a powerful modality for translational cancer research, a precise evaluation of how accurately patient responses correlate with matching PDXs in a large, heterogeneous population is needed for assessing the utility of this platform for preclinical drug-testing and personalized patient cancer treatment. Patients and methods Tumors obtained from surgical or biopsy procedures from 237 cancer patients with a variety of solid tumors were… CONTINUE READING
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