Patient derived organoids to model rare prostate cancer phenotypes

  title={Patient derived organoids to model rare prostate cancer phenotypes},
  author={Loredana Puca and Rohan Bareja and Davide Prandi and Reid Shaw and Matteo Benelli and Wouter R. Karthaus and Judy Hess and Michael Sigouros and Adam J Donoghue and Myriam Kossai and Dong Gao and Joanna Cyrta and Verena Sailer and Aram Vosoughi and Chantal Pauli and Yelena Churakova and Cynthia Cheung and Lesa Dayal Deonarine and Terra J McNary and Rachele Rosati and Scott T Tagawa and David M. Nanus and Juan Miguel Mosquera and Charles L Sawyers and Yu Chen and Giorgio Inghirami and Rema Rao and Carla M. Grandori and Olivier Elemento and Andrea Sboner and Francesca Demichelis and Mark A. Rubin and Himisha Beltran},
  booktitle={Nature Communications},
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or as a mechanism of treatment resistance in patients with pre-existing castration-resistant prostate cancer. There are few available models to study neuroendocrine prostate cancer. Here, we report the generation and characterization of tumor organoids derived from needle biopsies of… CONTINUE READING
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