Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice.

@article{Cole2010PatientAD,
  title={Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice.},
  author={Robert N Cole and Nazanin Ghazanfari and Shyuan T Ngo and Othon L. Gervasio and Stephen W Reddel and William Phillips},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 17},
  pages={
          3217-29
        }
}
The postsynaptic muscle-specific kinase (MuSK) coordinates formation of the neuromuscular junction (NMJ) during embryonic development. Here we have studied the effects of MuSK autoantibodies upon the NMJ in adult mice. Daily injections of IgG from four MuSK autoantibody-positive myasthenia gravis patients (MuSK IgG; 45 mg day(1)i.p. for 14 days) caused reductions in postsynaptic ACh receptor (AChR) packing as assessed by fluorescence resonance energy transfer (FRET). IgG from the patients with… CONTINUE READING
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