Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

@article{Gonsalves2014PatientAT,
  title={Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.},
  author={Wilson I Gonsalves and Michelle R. Mahoney and Daniel J. Sargent and Garth D. Nelson and Steven Robert Alberts and Frank A. Sinicrope and Richard M. Goldberg and Paul J. Limburg and Stephen N. Thibodeau and Axel F Grothey and Joleen M Hubbard and Emily T Chan and Suresh Kumar Ramachandran Nair and Jeffrey L. Berenberg and Robert R McWilliams},
  journal={Journal of the National Cancer Institute},
  year={2014},
  volume={106 7}
}
BACKGROUND KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. METHODS Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III adjuvant trial for stage III colon cancer completed a patient questionnaire. Primary tumors were assessed for KRAS and BRAF (V600E) mutations and defective mismatch repair (dMMR) status. Logistic regression… CONTINUE READING
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