Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

@article{Berk2011PathwaysUN,
  title={Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors},
  author={Michael Berk and Fl{\'a}vio Kapczinski and Ana C. Andreazza and Olivia M. Dean and Francesco Giorlando and Michael Maes and Mehmet Y{\"u}cel and C. S. Gama and S. Dodd and Brian Dean and Pedro V. S. Magalhaes and Paul G. Amminger and Patrick D McGorry and Gin S. Malhi},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2011},
  volume={35},
  pages={804-817}
}

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References

SHOWING 1-10 OF 245 REFERENCES
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
TLDR
The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BD NF as a biomarker in BD.
Mitochondrial Dysfunction and Oxidative Stress in Bipolar Disorder
Neuroplasticity and cellular resilience in mood disorders
TLDR
It is proposed that impairments of neuroplasticity and cellular resilience may underlie the pathophysiology of mood disorders, and further that optimal long-term treatment for these severe illnesses may only be achieved by the early and aggressive use of agents with neurotrophic/ neuroprotective effects.
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder.
TLDR
Examination of cytokine and BDNF levels in bipolar I disorder patients found that failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these have the potential to serve as markers of illness progression in BD.
The nature of bipolar disorder.
TLDR
Regulation of gene expression and identification of factors regulating neuroplasticity and neurotrophic events in the central nervous system in bipolar disorder are 2 of the more recent approaches contributing to clarification of the pathophysiology and potential treatment options.
Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode
Allostatic load in bipolar disorder: Implications for pathophysiology and treatment
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
TLDR
A hypothesis integrating current concepts of neurotransmission and hypothalamus–pituitary–adrenal (HPA) axis dysregulation with findings on immunological alterations and alterations in brain morphology in MD is presented.
Increased serum neurotrophin-4/5 levels in bipolar disorder.
...
...