Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors

@article{Berk2011PathwaysUN,
  title={Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors},
  author={Michael Berk and Fl{\'a}vio Kapczinski and Ana C. Andreazza and Olivia M. Dean and Francesco Giorlando and Michael Maes and Mehmet Y{\"u}cel and C. S. Gama and S. Dodd and Brian Dean and Pedro V. S. Magalhaes and Paul G. Amminger and Patrick D McGorry and Gin S. Malhi},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2011},
  volume={35},
  pages={804-817}
}
View on Elsevier
dosequis.colorado.edu
979 Citations
Highly Influential Citations
44
Background Citations
386
Methods Citations
17
Results Citations
24

Figures and Tables from this paper

979 Citations

Neuroinflammation and excitatory symptoms in bipolar disorder
TLDR
Evidence indicating specific alterations of the inflammatory response during manic and mixed states of BD is found, which may help to clarify some of the complex mechanisms underlying the development of excitatory symptoms and suggest a potential role for drugs targeting the inflammatory system as new therapeutic options.
Peripheral markers and the pathophysiology of bipolar disorder
TLDR
Systemic changes that link bipolar disorder to clinical comorbidity, cognitive dysfunction, disability and early mortality are becoming evident and longitudinal studies with population-based samples and clinical trials incorporating biomarkers are needed to shed light upon the notion of a multisystem involvement in bipolar disorder.
The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment.
TLDR
The data suggested that BD might be associated with neuronal and glial cellular impairment in specific brain areas, including the prefrontal cortex, and how these molecular pathways interact and their connection to the complex clinical manifestations observed in BD is attempted.
Inflammation as a Mechanism of Bipolar Disorder Neuroprogression.
TLDR
This chapter put forth the evidence of immune markers from autoimmune disorders, chronic infections, and gut-brain axis that lead to BD neuroprogression and highlighted the peripheral and central inflammatory components measured along with BD progression.
IMMUNE SYSTEM ALTERATIONS AND EXCITATORY SYMPTOMS IN AFFECTIVE DISORDERS
TLDR
Evidence indicating specific alterations of the inflammatory response during manic and mixed states of BD is found, which may help to clarify some of the complex mechanisms underlying the development of excitatory symptoms and suggest a potential role for drugs targeting the inflammatory system as new therapeutic options.
Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers
TLDR
An increase in the levels of proinflammatory cytokines during acute episodes with a decrease in neurotrophic support is found, which together cause plastic changes in the mood regulating areas of the brain and neuroprogression of the bipolar diathesis.
Neurooxidative and neuronitrosative mechanisms in bipolar disorder: Evidence and implications
Concepts of Neuroinflammation and Their Relationship With Impaired Mitochondrial Functions in Bipolar Disorder
TLDR
A deeper understanding of BD pathophysiology and identification of associated biomarkers of neuroinflammation are needed to facilitate early diagnosis and treatment of this debilitating disorder.
Biological mechanisms underlying neuroprogression in bipolar disorder.
The Neurobiology of Bipolar Disorder.
Bipolar disorders are severe and have a high prevalence; despite this, the neurobiological mechanisms are far from being elucidated, and this limits the development of new treatments. Although the…
...
...

References

SHOWING 1-10 OF 245 REFERENCES
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
TLDR
The present review discusses the role of BDNF as a mediator of the neuroplastic changes that occur in portion with mood episodes and the potential use of serum BD NF as a biomarker in BD.
Mitochondrial Dysfunction and Oxidative Stress in Bipolar Disorder
Neuroplasticity and cellular resilience in mood disorders
TLDR
It is proposed that impairments of neuroplasticity and cellular resilience may underlie the pathophysiology of mood disorders, and further that optimal long-term treatment for these severe illnesses may only be achieved by the early and aggressive use of agents with neurotrophic/ neuroprotective effects.
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder.
TLDR
Examination of cytokine and BDNF levels in bipolar I disorder patients found that failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these have the potential to serve as markers of illness progression in BD.
The nature of bipolar disorder.
TLDR
Regulation of gene expression and identification of factors regulating neuroplasticity and neurotrophic events in the central nervous system in bipolar disorder are 2 of the more recent approaches contributing to clarification of the pathophysiology and potential treatment options.
Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
Decreased Plasma Brain Derived Neurotrophic Factor Levels in Unmedicated Bipolar Patients During Manic Episode
Allostatic load in bipolar disorder: Implications for pathophysiology and treatment
The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression
TLDR
A hypothesis integrating current concepts of neurotransmission and hypothalamus–pituitary–adrenal (HPA) axis dysregulation with findings on immunological alterations and alterations in brain morphology in MD is presented.
Increased serum neurotrophin-4/5 levels in bipolar disorder.
...
...