Pathways to nephron loss starting from glomerular diseases-insights from animal models.

@article{Kriz2005PathwaysTN,
  title={Pathways to nephron loss starting from glomerular diseases-insights from animal models.},
  author={Wilhelm Kriz and Michel Lehir},
  journal={Kidney international},
  year={2005},
  volume={67 2},
  pages={
          404-19
        }
}
Studies of glomerular diseases in animal models show that progression toward nephron loss starts with extracapillary lesions, whereby podocytes play the central role. If injuries remain bound within the endocapillary compartment, they will undergo recovery or be repaired by scaring. Degenerative, inflammatory and dysregulative mechanisms leading to nephron loss are distinguished. In addition to several other unique features, the dysregulative mechanisms leading to collapsing glomerulopathy are… Expand
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