Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency.

  title={Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency.},
  author={Loredana Quadro and L. Kevin Hamberger and Max E. Gottesman and Fengwei Wang and Vittorio Colantuoni and William S. Blaner and Cathy Lee Mendelsohn},
  volume={146 10},
Circulating retinoids (vitamin A and its derivatives) are found predominantly as retinol bound to retinol-binding protein (RBP), which transports retinol from liver stores to target tissues, or as retinyl ester incorporated in lipoproteins of dietary origin. The transport of retinoids from maternal to fetal circulation is poorly understood, especially under conditions of inadequate dietary vitamin A intake. Here we present RBP-/- mice as a tunable model of embryonic vitamin A deficiency. This… CONTINUE READING
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